Single influenza A viruses induce nanoscale cellular reprogramming at the virus-cell interface
Lukas Broich, Hannah Wullenkord, Maria Kaukab Osman, Yang Fu, Peter Reuther, Mark Broenstrup, Christian Sieben^#
bioRxiv (2024), ^#corresponding author

The bat Influenza A virus subtype H18N11 induces nanoscale MHCII clustering upon host cell attachment
Maria Kaukab Osman, Jonathan Robert, Lukas Broich, Dennis Frank, Robert Grosse, Martin Schwemmle, Antoni Wrobel, Kevin Ciminski, Christian Sieben^#, Peter Reuther^#
bioRxiv (2024), ^#corresponding authors

H7N7 viral infection elicits pronounced, sex-specific neuroinflammatory responses in vitro
Lea Gabele, Isabell Bochow, Nele Rieke, Christian Sieben, Kristin Michaelsen-Preusse, Shirin Hosseini, Martin Korte
Frontiers in Cellular Neuroscience (2024)

An improved workflow for the quantification of orthohantavirus infection using automated imaging and flow cytometry
Laura Menke, Christian Sieben^#
Viruses (2024), ^#corresponding author

Nanoscale organization of the endogenous ASC speck
Ivo M. Glück, Grusha Primal Mathias, Sebastian Strauss, Thomas S. Ebert, Che Stafford, Ganesh Agam, Suliana Manley, Veit Hornung, Ralf Jungmann, Christian Sieben^#, Don C. Lamb^#
iScience (2023), ^#co-corresponding authors

Relevance of host cell surface glycan structure for cell specificity of influenza A virus Markus Kastner, Andreas Karner, Rong Zhu, Qiang Huang, Andreas Geissner, Anne Sadewasser, Markus Lesch, Xenia Wörmann, Alexander Karlas, Peter H. Seeberger, Thorsten Wolff, Peter Hinterdorfer, Andreas Herrmann, Christian Sieben ^#
Viruses (2023) ^#corresponding author

Advanced fluorescence microscopy in respiratory virus cell biology
Enyu Xie, Shazeb Ahmad, Redmond P. Smyth, Christian Sieben^#
Advances in Virus Research (2023), ^#corresponding author

Structural basis of NINJ1-mediated plasma membrane rupture in cell death

Morris Degen, José Carlos Santos, Kristyna Pluhackova, Gonzalo Cebrero, Saray Ramos, Gytis Jankevicius, Ella Hartenian, Undina Guillerm, Stefania A Mari, Bastian Kohl, Daniel J Müller, Paul Schanda, Timm Maier, Camilo Perez, Christian Sieben, Petr Broz, Sebastian Hiller
Nature (2023)

Advances in fluorescence microscopy for orthohantavirus research
Laura Menke, Hannah S Sperber, Amit Koikkarah Aji, Salvatore Chiantia, Roland Schwarzer, Christian Sieben^#
Microscopy (2023) ^#corresponding author

SMER28 attenuates PI3K/mTOR signaling by direct inhibition of PI3K p110 delta
Marco Kirchenwitz, Stephanie Stahnke, Silvia Prettin, Malgorzata Borowiak, Laura Menke, Christian Sieben, Carmen Birchmeier, Klemens Rottner, Theresia EB Stradal, Anika Steffen
Cells (2022)

Characterization of Hantavirus N Protein Intracellular Dynamics and Localization
Robert-William Welke, Hannah Sabeth Sperber, Amit Koikkarah, Laura Menke, Christian Sieben, Detlev Herbert Krüger, Salvatore Chiantia, Andreas Herrmann, Roland Schwarzer
Viruses (2022)

3D structure from 2D microscopy images using deep learning Authors
Benjamin Blundell, Christian Sieben, Suliana Manley, Ed Rosten, QueeLim Ch’ng, Susan Cox
Frontiers in Bioinformatics (2021)

Pseudomonas aeruginosa PA14 produces R-bodies, extendable protein polymers with roles in host colonization and virulence Bryan Wang, Yu-Cheng Lin, Alejandro Vasquez-Rifo, Jeanyoung Jo, Alexa Price-Whelan, Shujuan Tao McDonald, Lewis M Brown, Christian Sieben, Lars EP Dietrich Nature Communications (2021)

Application of Super-Resolution and Advanced Quantitative Microscopy to the Spatio-Temporal Analysis of Influenza Virus Replication
Emma Touizer, Christian Sieben, Ricardo Henriques, Mark Marsh, Romain F Laine
Viruses (2021)

Nanoscale Pattern Extraction from Relative Positions of Sparse 3D Localizations
Alistair P Curd, Joanna Leng, Ruth E Hughes, Alexa J Cleasby, Brendan Rogers, Chi H Trinh, Michelle A Baird, Yasuharu Takagi, Christian Tiede, Christian Sieben, Suliana Manley, Thomas Schlichthaerle, Ralf Jungmann, Jonas Ries, Hari Shroff, Michelle Peckham
Nano Letters (2020)

Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation
Sieben C^#, Sezgin E, Eggeling C, Manley S^#
PLoS Pathogens (2020) ^#co-corresponding authors

Initial Step of Virus Entry: Virion Binding to Cell-Surface Glycans
Koehler M, Delguste M, Sieben C, Gillet L, Alsteens D
Annual Review of Virology (2020)

Inhibition of influenza virus activity by the bovine seminal plasma protein PDC-109
Welke R, Haralampiev I, Schröter F, Braun B, Herrmann A, Sieben C^#, Müller P^#
European Biophysics Journal (2019) ^#co-corresponding authors

Waveguide-PAINT offers an open platform for large field-of-view super-resolution imaging
Archetti A, Glushkov E, Sieben C, Stroganov A, Radenovic A, Manley
Nature Communications (2019)

RNAi-based Small Molecule Repositioning Reveals Clinically Approved Urea-Based Kinase Inhibitors as Broadly Active Antivirals Lesch M, Luckner M, Meyer M, Gravenstein I, Raftery M, Sieben C, Martin L, Imai A, Welke R, Schönrich G, Herrmann A, Meyer TF, Karlas A
PLoS Pathogens (2019)

Single-molecule dynamics and genome-wide transcriptomics reveal that NF-kB (p65)-DNA binding times can be decoupled from transcriptional activation
Callegari A*, Sieben C*, Suter D, Fierz B, Mazza D, Manley S
PLoS Genetics (2019) *equal author contribution

Multi-color single particle reconstruction of protein complexes
Sieben C*^,#, Banterle N*, Douglass KM, Gönczy P, Manley S^#
Nature Methods (2018) ^#co-corresponding authors, *equal author contribution

Super-resolution microscopy to decipher multi-molecular assemblies
Sieben C, Douglass KM, Guichard P, Manley S
Current Opinion in Structural Biology (2018)

TORC1 Organised in Inhibited Domains (TOROIDs) regulate TORC1 activity
Prouteau M, Desfosses A, Sieben C, Mozaffari NL, Bourgoint C, Demurtas D, Mitra AK, Guichard P, Manley S, Loewith R
Nature (2017)

Stochastic Model of Acidification Activation of Hemagglutinin and Escape of Influenza Viruses from an Endosome
Lagache T, Sieben C, Herrmann A, Holcman D
Frontiers in Physics (2017)

Single virus force spectroscopy: The ties that bind
Sieben C^#, Herrmann A^#
Nature Nanotechnology (2017) ^#co-corresponding authors

Super-resolution imaging of multiple cells by optimized flat-field epi-illumination
Douglass KM, Sieben C, Archetti A, Lambert A, Manley S
*Nature Photonics *(2016)

RNA degradation and diffusion act as a bottleneck for the influenza A infection efficiency
Schelker M, Mair C, Jolmes F, Welke RW, Klipp E, Herrmann A, Flöttmann M^#, Sieben C ^#
PLoS Computational Biology (2016) ^#co-corresponding author

A Genetic characterisation of an adapted pandemic 2009 H1N1 influenza virus that reveals improved replication rates in human lung epithelial cells
Wörmann X, Lesch M, Welke RW, Okonechnikov K, Abdurishid M, Sieben C, Geissner A, Brinkmann V, Kastner K, Karner A, Zhu R, Hinterdorfer P, Anish C, Seeberger PH, Herrmann A, Meyer TF, Karlas A
Virology (2016)

Single-virus force spectroscopy unravels molecular details of virus infection
Herrmann A^#, Sieben C ^#
*Integrative Biology * (2015) ^# co-corresponding author

Receptor binding and pH stability - How influenza A virus hemagglutinin affects host-specific virus infection
Mair CM, Ludwig K, Herrmann A, Sieben C
Biochimica et Biophysica Acta (BBA)-Biomembranes (2014)

Influenza A matrix protein M1 multimerizes upon binding to lipid membranes
Hilsch M, Goldenbogen B, Sieben C, Höfer CT, Rabe JP, Klipp E, Herrmann A, Chiantia S
Biophysical Journal (2014)

Alteration of protein levels during influenza virus H1N1 infection in host cells: a proteomic survey of host and virus reveals differential dynamics
Kummer S, Flöttmann M, Schwanhäusser B, Sieben C, Veit M, Selbach M, Klipp E, Herrmann A
PloS One (2014)

pH-controlled two-step uncoating of influenza virus
Li S*, Sieben C*, Ludwig K, Höfer C T, Chiantia S, Herrmann A, Eghiaian F, Schaap I A T
Biophysical Journal (2014) *equal author contribution

Virus inhibition induced by polyvalent nanoparticles of different sizes
Vonnemann J, Sieben C, Wolff C, Ludwig K, Böttcher C, Herrmann A, Haag R
Nanoscale (2014)

Heterogeneity of AMPA receptor trafficking and molecular interactions revealed by super-resolution analysis of live cell imaging
Hoze N, Nair D, Hosy E, Sieben C, Manley S, Herrmann A, Sibarita JB, Choquet D, Holcman D
PNAS (2012)

Influenza virus binds its host cell using multiple dynamic interactions
Sieben C*, Kappel C*, Zhu R, Wozniak A, Rankl C, Hinterdorfer P, Grubmüller H, Herrmann A
PNAS (2012) *equal author contribution

** Inhibition of influenza virus activity by multivalent glycoarchitectures with matched sizes**
Papp I , Sieben C, Sisson A L, Kostka J, Böttcher C, Ludwig K, Herrmann A, Haag R
ChemBioChem (2011) *equal author contribution

Bending and puncturing the influenza lipid envelope
Li S, Eghiaian F, Sieben C, Herrmann A, Schaap IAT
Biophysical Journal (2011)

Inhibition of Influenza Virus Infection by Multivalent Sialic‐Acid‐Functionalized Gold Nanoparticles
Papp I, Sieben C, Ludwig K, Roskamp M, Böttcher C, Schlecht S, Herrmann A, Haag R
Small (2010)

Interaction of the K+‐channel KAT1 with the coat protein complex II coat component Sec24 depends on a di‐acidic endoplasmic reticulum export motif
Sieben C*, Mikosch M*, Brandizzi F, Homann U
The Plant Journal (2008) *equal author contribution

Abscisic acid triggers the endocytosis of the Arabidopsis KAT1 K+ channel and its recycling to the plasma membrane
Sutter JU, Sieben C, Hartel A, Eisenach C, Thiel G, Blatt MR
Current Biology (2007)

A plant homolog of animal chloride intracellular channels (CLICs) generates an ion conductance in heterologous systems
Elter A, Hartel A, Sieben C, Hertel B, Fischer-Schliebs E, Lüttge U, Moroni A, Thiel G
*Journal of Biological Chemistry *(2007)